[HTML][HTML] Pathogenesis of endometriosis: the genetic/epigenetic theory

PR Koninckx, A Ussia, L Adamyan, A Wattiez… - Fertility and sterility, 2019 - Elsevier
Objective To study the pathophysiology of endometriosis. Design Overview of observations
on endometriosis. Setting Not applicable. Patient (s) None. Interventions (s) None. Main …

Theories on the pathogenesis of endometriosis

S Sourial, N Tempest… - International journal of …, 2014 - Wiley Online Library
Endometriosis is a common, chronic inflammatory disease defined by the presence of
extrauterine endometrial tissue. The aetiology of endometriosis is complex and …

[HTML][HTML] Pathogenesis of deep endometriosis

S Gordts, P Koninckx, I Brosens - Fertility and sterility, 2017 - Elsevier
The pathophysiology of (deep) endometriosis is still unclear. As originally suggested by
Cullen, change the definition “deeper than 5 mm” to “adenomyosis externa.” With the …

Uterine stem cells: from basic research to advanced cell therapies

X Santamaria, A Mas, I Cervelló… - Human Reproduction …, 2018 - academic.oup.com
BACKGROUND Stem cell research in the endometrium and myometrium from animal
models and humans has led to the identification of endometrial/myometrial stem cells and …

Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis

CE Gargett, KE Schwab, JJ Brosens… - Molecular human …, 2014 - academic.oup.com
The pathogenesis of early-onset endometriosis has recently been revisited, sparked by the
discovery of endometrial stem/progenitor cells and their possible role in endometriosis, and …

Endometriosis: a life cycle approach?

I Brosens, P Puttemans, G Benagiano - American journal of obstetrics and …, 2013 - Elsevier
To improve the still fragmented understanding of endometriosis, a life cycle approach was
adopted that revealed unexpected aspects of the natural history of the disease throughout a …

[HTML][HTML] Sorafenib inhibits growth, migration, and angiogenic potential of ectopic endometrial mesenchymal stem cells derived from patients with endometriosis

A Moggio, G Pittatore, P Cassoni, GL Marchino… - Fertility and …, 2012 - Elsevier
OBJECTIVE: To characterize the proliferation, migration, and angiogenic properties of
mesenchymal stem cells (MSC) from ectopic and eutopic endometrial tissue and to …

Ovarian endometrioma in the adolescent: a plea for early-stage diagnosis and full surgical treatment

S Gordts, P Puttemans, S Gordts, I Brosens - Gynecological surgery, 2015 - Springer
The incidence and severity of endometriosis in adolescent are comparable with the
incidence in adult women. The mean delay between the onset of symptoms and the final …

Endometrial adult/progenitor stem cells: pathogenetic theory and new antiangiogenic approach for endometriosis therapy

G Pittatore, A Moggio, C Benedetto… - Reproductive …, 2014 - journals.sagepub.com
The cyclical arrival of endometrial cells into the abdominal cavity through retrograde flux at
menstruation represents the etiopathogenetic basis of endometriosis. The endometrium has …

[HTML][HTML] Regeneration and anti-inflammatory effects of stem cells and their extracellular vesicles in gynecological diseases

X Zheng, D Zhao, Y Liu, Y Jin, T Liu, H Li… - Biomedicine & …, 2023 - Elsevier
There are many gynecological diseases, among which breast cancer (BC), cervical cancer
(CC), endometriosis (EMs), and polycystic ovary syndrome (PCOS) are common and difficult …