To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

Biological clocks are autonomous anticipatory oscillators that play a critical role in the
organization and information processing from genome to whole organisms. Transformative …

Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

INTRODUCTION Temporally consolidated behaviors such as sleep normally occur in
synchrony with endogenous circadian rhythms and both have been reported to contribute to …

The genomes of large multicellular eukaryotes are mostly comprised of non-protein coding
DNA. Although there has been much agreement that a small fraction of these genomes has …