The potential of cancer immunotherapy relies on the mobilization of immune cells capable of
producing antitumour cytokines and effectively killing tumour cells. These are major …

RORγt, the master transcription factor for cytokine interleukin (IL)-17, is expressed explicitly
in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans. Since …

Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …

Background & Aims Enterotoxigenic Bacteroides fragilis (ETBF) is strongly associated with
the occurrence of inflammatory bowel disease (IBD), colitis-associated colorectal cancer …

The pathogenesis of inflammatory bowel disease (IBD) is still unclear. Immune dysfunction
may play a key role in the pathogenesis of IBD, in which the role of CD4+ T helper (Th) cells …

A properly mounted immune response is indispensable for recognizing and eliminating
danger arising from foreign invaders and tissue trauma. However, the'inflammatory …

Chronic inflammation can drive tumor development. Here, we have identified microRNA-
146a (miR-146a) as a major negative regulator of colonic inflammation and associated …

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was
recently implicated in various autoimmune disorders. Tregs are responsible for the …

The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive
immune responses, antagonizing each other in immune disorders. Th17/Treg balance is …