Influenza is a long-standing health problem. For treatment of seasonal flu and possible
pandemic infections, there is a need to develop new anti-influenza drugs that have good …

Shikimic acid is a key intermediate for the synthesis of the antiviral drug oseltamivir
(Tamiflu®). Shikimic acid can be produced via chemical synthesis, microbial fermentation …

Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …

Background Data are limited on the impact of neuraminidase inhibitor (NAI) treatment on
avian influenza A (H7N9) virus RNA shedding. Methods In this multicenter, retrospective …

Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of high-volume fuels …

Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including
the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple …

Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine
esterases responsible for the hydrolysis of ester and amide bonds present in a number of …

В последние годы вирусные инфекции характеризуются выраженной
пневмотропностью, приводящей к развитию пневмоний, которые занимают ведущее …

Background Combating infectious diseases caused by influenza virus is a major challenge
due to its resistance to available drugs and vaccines, side effects, and cost of treatment …

Background. It is unclear if higher-dose oseltamivir provides benefit beyond the standard
dose in influenza patients who require hospitalization. Methods. A prospective intervention …