FtsZ inhibitors as a new genera of antibacterial agents
S Tripathy, SK Sahu - Bioorganic chemistry, 2019 - Elsevier
The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial
pathogens have demanded the discovery and development of new antibacterial agents. A …
pathogens have demanded the discovery and development of new antibacterial agents. A …
Targeting the bacterial division protein FtsZ
KA Hurley, TMA Santos, GM Nepomuceno… - Journal of medicinal …, 2016 - ACS Publications
Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …
Synthesis and investigation of novel benzimidazole derivatives as antifungal agents
The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …
strains have resulted in an increase in demand for new antifungal agents. Various …
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ
K Haranahalli, S Tong, I Ojima - Bioorganic & medicinal chemistry, 2016 - Elsevier
With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …
Recent progress of bacterial FtsZ inhibitors with a focus on peptides
H Han, Z Wang, T Li, D Teng, R Mao, Y Hao… - The FEBS …, 2021 - Wiley Online Library
In recent years, the rise of antibiotic resistance has become a primary health problem. With
the emergence of bacterial resistance, the need to explore and develop novel antibacterial …
the emergence of bacterial resistance, the need to explore and develop novel antibacterial …
Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs
L Rodrigues, P Cravo, M Viveiros - Expert review of anti-infective …, 2020 - Taylor & Francis
ABSTRACT Introduction: In 2018, an estimated 377,000 people developed multidrug-
resistant tuberculosis (MDR-TB), urging for new effective treatments. In the last years, it has …
resistant tuberculosis (MDR-TB), urging for new effective treatments. In the last years, it has …
Impact of FtsZ inhibition on the localization of the penicillin binding proteins in methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen of
acute clinical importance. Combination treatment with an FtsZ inhibitor potentiates the …
acute clinical importance. Combination treatment with an FtsZ inhibitor potentiates the …
Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ
X Li, S Ma - European journal of medicinal chemistry, 2015 - Elsevier
Currently, wide-spread antimicrobials resistance among bacterial pathogens continues
being a dramatically increasing and serious threat to public health, and thus there is a …
being a dramatically increasing and serious threat to public health, and thus there is a …
Structure-guided design of a fluorescent probe for the visualization of FtsZ in clinically important gram-positive and gram-negative bacterial pathogens
E Ferrer-González, J Fujita, T Yoshizawa, JM Nelson… - Scientific reports, 2019 - nature.com
Addressing the growing problem of antibiotic resistance requires the development of new
drugs with novel antibacterial targets. FtsZ has been identified as an appealing new target …
drugs with novel antibacterial targets. FtsZ has been identified as an appealing new target …
Identification of phenoxyalkylbenzimidazoles with antitubercular activity
NS Chandrasekera, T Alling, MA Bailey… - Journal of medicinal …, 2015 - ACS Publications
We conducted an evaluation of the phenoxyalkylbenzimidazole series based on the
exemplar 2-ethyl-1-(3-phenoxypropyl)-1 H-benzo [d] imidazole for its antitubercular activity …
exemplar 2-ethyl-1-(3-phenoxypropyl)-1 H-benzo [d] imidazole for its antitubercular activity …