Clinical phenotypes of heart failure with preserved ejection fraction to select preclinical animal models

WB van Ham, EL Kessler, MIFJ Oerlemans… - Basic to Translational …, 2022 - jacc.org
At least one-half of the growing heart failure population consists of heart failure with
preserved ejection fraction (HFpEF). The limited therapeutic options, the complexity of the …

[HTML][HTML] Impact of myeloid differentiation protein 1 on cardiovascular disease

X Jiang, P Ning, F Yan, J Wang, W Cai… - Biomedicine & …, 2023 - Elsevier
Cardiovascular disease remains the leading cause of disability and mortality worldwide and
a significant global burden. Many lines of evidence suggest complex remodeling responses …

[HTML][HTML] The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and …

M Yan, S Liu, W Zeng, Q Guo, Y Mei, X Shao… - Biomedicine & …, 2023 - Elsevier
Diabetic cardiomyopathy (DCM) is an important complication leading to the death of patients
with diabetes, but there is no effective strategy for clinical treatments. Fufang Zhenzhu …

Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-κB signaling pathway

C Qian, D Xu, J Wang, Y Luo, T Jin, L Huang… - International …, 2024 - Elsevier
Growing evidence demonstrates that chronic low-grade inflammation, which is induced by
high-fat diet (HFD) or saturated fatty acid, plays an important role in the obesity-induced …

A simplified herbal formula improves cardiac function and reduces inflammation in mice through the TLR-mediated NF-κB signaling pathway

X Dong, X Han, X Zhang, S Li, Z Li, J Kang… - Frontiers in …, 2022 - frontiersin.org
Nuanxinkang tablet (NXK), a Chinese herbal formula, can improve heart function and quality
of life in patients with chronic heart failure (CHF). However, the mechanisms of action of NXK …

Toll-like Receptor 4 Differentially Modulates Cardiac Function in Response to Chronic Exposure to High-Fat Diet and Pressure Overload

L Tian, M Jarrah, H Herz, Y Chu, Y Xu, Y Tang, J Yuan… - Nutrients, 2023 - mdpi.com
Background/Aim: The impact of myocardial stressors such as high-fat diet (HFD) and
pressure overload has been extensively studied. Toll-like receptor 4 (TLR4) deficiency has …