Acetylcholinesterase inhibitors: a patent review (2008–present)
M Pohanka - Expert opinion on therapeutic patents, 2012 - Taylor & Francis
Introduction: Both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are
present in the body in large amounts. AChE is an important part of the cholinergic nervous …
present in the body in large amounts. AChE is an important part of the cholinergic nervous …
Design, synthesis and anti-Alzheimer's activity of novel 1, 2, 3-triazole-chromenone carboxamide derivatives
Alzheimer's disease (AD) is a well-known neurodegenerative disorder affecting millions of
old people worldwide and the corresponding epidemiological data highlights the …
old people worldwide and the corresponding epidemiological data highlights the …
Cholinesterase inhibitors: cardioprotection in Alzheimer's disease
F Monacelli, G Rosa - Journal of Alzheimer's Disease, 2014 - content.iospress.com
Alzheimer's disease is a life shortening disease, and the lack of disease modifying therapy
implies a huge impact on life expectancy as well as an outgrowing financial and …
implies a huge impact on life expectancy as well as an outgrowing financial and …
Excellent inhibition performance of low-toxicity Dibenzyldithiocarbamic Acid Zinc Salt self-assembled nano-film for copper corrosion in sulfuric acid
J Wang, Y Qiang, L Jiang, B Xiang, S Chen… - Journal of Molecular …, 2018 - Elsevier
The toxicities of corrosion inhibitors were evaluated by the method of Quantitative Structure
Activity Relationships (QSARs) and the results show that Dibenzyldithiocarbamic Acid Zinc …
Activity Relationships (QSARs) and the results show that Dibenzyldithiocarbamic Acid Zinc …
Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors
The reversible inhibition of acetylcholinesterase (AChE) has become a promising target for
the treatment of Alzheimer's disease (AD) which is mainly associated with low in vivo levels …
the treatment of Alzheimer's disease (AD) which is mainly associated with low in vivo levels …
Dual/multitargeted xanthone derivatives for Alzheimer's disease: where do we stand?
MI Cruz, H Cidade, M Pinto - Future Medicinal Chemistry, 2017 - Taylor & Francis
To date, the current therapy for Alzheimer's disease (AD) based on acetylcholinesterase
inhibitors is only symptomatic, being its efficacy limited. Hence, the recent research has …
inhibitors is only symptomatic, being its efficacy limited. Hence, the recent research has …
New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for
their anti-cholinergic activities against acetylcholinesterase (AChE) and …
their anti-cholinergic activities against acetylcholinesterase (AChE) and …
Identification of dual Acetyl-CoA carboxylases 1 and 2 inhibitors by pharmacophore based virtual screening and molecular docking approach
Acetyl-CoA carboxylase (ACC) is a crucial metabolic enzyme that plays a vital role in obesity-
induced type 2 diabetes and fatty acid metabolism. To identify dual inhibitors of Acetyl-CoA …
induced type 2 diabetes and fatty acid metabolism. To identify dual inhibitors of Acetyl-CoA …
Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations
Alzheimer's disease (AD), a progressive neurodegenerative disorder is the most common
cause of dementia among elderly people. To date, the successful therapeutic strategy to …
cause of dementia among elderly people. To date, the successful therapeutic strategy to …
Inhibitory activity on cholinesterases produced by aryl-phthalimide derivatives: green synthesis, in silico and in vitro evaluation
O Ruiz-Maciel, II Padilla-Martínez… - Medicinal Chemistry …, 2020 - Springer
Background Alzheimer's disease (AD) is characterized by cognitive impairment and loss of
immediate memory resulting from neuronal death in different brain areas, mainly those …
immediate memory resulting from neuronal death in different brain areas, mainly those …