Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …

This article is published as part of a supplement sponsored by Kidney Disease: Improving
Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of …

The microbes and microbial pathways that influence host inflammatory disease progression
remain largely undefined. Here, we show that variation in atherosclerosis burden is partially …

Background: Sodium–glucose cotransporter-2 inhibitors (SGLT2is) decrease serum urate
levels, but whether this translates into prevention of recurrent flares among patients with …

Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …

Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay
urate-lowering therapy (ULT) for treating hyperuricaemia in patients with gout. However, not …

A direct relationship between serum uric acid levels and hypertension, cardiovascular, renal
and metabolic diseases has been reported in many basic and epidemiological studies …

Objective To investigate the temporal association between the first diagnosis of gout and
cardiovascular events in the short term. Methods We performed a self‐controlled case series …

Endothelial dysfunction (ED) is characterized by imbalanced vasodilation and
vasoconstriction, elevated reactive oxygen species (ROS), and inflammatory factors, as well …