Although innovative targeted therapies have positively revolutionized psoriasis treatment
shifting treatment goals to complete or almost complete skin clearance, primary or …

In the era of biologic therapies, methotrexate (MTX), a classic immunomodulator, is still the
cornerstone of systemic treatment of psoriasis. MTX has been used for many years …

Despite its effectiveness in treating inflammatory diseases and various malignancies,
methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased …

The aim of this study was to prepare and characterize topical methotrexate (MTX) with
different percentages (0.05%, 0.1%, 0.25% and 0.5%) entrapped in deformable liposomes …

The systemic administration of methotrexate (MTX), a commonly used, antineoplastic drug
which is also used in cutaneous disorders, is primarily associated with prolonged retention …

Background Oral ulcers caused by methotrexate (MTX) at low doses are a known side effect
of this drug. Although increasingly more patients are medicated with MTX, these painful …

Background Skin toxicity during low-dose methotrexate therapy is rare, ill described, and
reported to have nonspecific histologic characteristics. Thus, misdiagnosis is common in …

Background Methotrexate cutaneous ulceration is a rare methotrexate complication, and has
only been described in case reports and case series. Objective To document patient …

Aging, exposure to oxidants, infectious pathogens, inflammogens, ultraviolet radiation and
other environmental and genetic factors can result in the development of various skin …

The first limiting barrier for the transport in the skin is the stratum corneum; different
strategies have been developed to overcome this barrier, including chemical enhancers …