The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene
expression by catalyzing the removal of acetyl groups, stimulating chromatin condensation …

In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Recently, despite the great success achieved by the so‐called “magic bullets” in the
treatment of different diseases through a marked and specific interaction with the target of …

Dysregulation of gene expression is a frequent occurrence in oral squamous cell carcinoma
(OSCC). However, accumulating evidence suggests that in contrast to genetics, epigenetic …

Squamous cell carcinoma of the oral region (OSCC) is one of the most common and highly
aggressive malignancies worldwide, despite the fact that significant results have been …

Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis
and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy …

Vorinostat is a potent histone deacetylase inhibitor that blocks the catalytic site of these
enzymes. A large number of cellular proteins are modified post-translationally by acetylation …