A concise review covering updated presence and role of 2-phenethylamines in medicinal
chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are …

Recent studies of the CMS illustrate the increasing complexity of the genetics and
pathophysiological mechanisms involved. With therapy tailored for the underlying disease …

Next generation sequencing techniques were recently used to show mutations in COL13A1
cause synaptic basal lamina-associated congenital myasthenic syndrome type 19. Animal …

Acetylcholine receptor deficiency is the most common form of the congenital myasthenic
syndromes, a heterogeneous collection of genetic disorders of neuromuscular transmission …

Congenital myasthenic syndromes (CMS) are characterized by fatigable muscle weakness
resulting from impaired neuromuscular transmission. β2-adrenergic agonists are an effective …

Abstract β2-Adrenoceptors (β2-ARs) are the most abundant subtype of adrenergic receptors
in skeletal muscles. Their activation via a stabilization of postsynaptic architecture has …

Increasing evidence indicates that, first, the sympathetic nervous system interacts
extensively with both vasculature and skeletal muscle fibers near neuromuscular junctions …

The β-adrenergic agonists salbutamol and ephedrine have proven to be effective as
therapies for human disorders of the neuromuscular junction, in particular many subsets of …

Objectives Inherited defects of the neuromuscular junction (NMJ) comprise an increasingly
diverse range of diseases. Several recently identified genes highlight the overlap between …

Adrenaline and noradrenaline, released as hormones and/or neurotransmitters, exert
diverse physiological functions in vertebrates, and teleost fishes are widely used as model …