Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides
has been a focus point of research. The prediction of signal peptides and protein subcellular …

The transposon Tn21 and a group of closely related transposons (the Tn21 family) are
involved in the global dissemination of antibiotic resistance determinants in gram-negative …

Background Predicting protein function and structure from sequence is one important
challenge for computational biology. For 26 years, most state-of-the-art approaches …

We describe and validate a new membrane protein topology prediction method, TMHMM,
based on a hidden Markov model. We present a detailed analysis of TMHMM's performance …

A novel method to model and predict the location and orientation of alpha helices in
membrane-spanning proteins is presented. It is based on a hidden Markov model (HMM) …

An inherent problem in transmembrane protein topology prediction and signal peptide
prediction is the high similarity between the hydrophobic regions of a transmembrane helix …

The cellular attributes of a protein, such as which compartment of a cell it belongs to and
how it is associated with the lipid bilayer of an organelle, are closely correlated with its …

We show that amino acid covariation in proteins, extracted from the evolutionary sequence
record, can be used to fold transmembrane proteins. We use this technique to predict …

A second gene for autosomal dominant polycystic kidney disease was identified by
positional cloning. Nonsense mutations in this gene (PKD2) segregated with the disease in …

The plant hormone auxin regulates various developmental processes including root
formation, vascular development, and gravitropism. Mutations within the AUX1 gene confer …