Early-onset Alzheimer's disease: what is missing in research?
Abstract Purpose of Review Early-onset Alzheimer's disease (EOAD), defined as
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
Alzheimer's disease genetics: from the bench to the clinic
Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
Y Zhang, N Huang, F Yan, H Jin, S Zhou, J Shi… - Behavioural brain …, 2018 - Elsevier
It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM),
and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and …
and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and …
[HTML][HTML] Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's
biochemical dissection of β-amyloid in 1984, the" amyloid hypothesis" of Alzheimer's …
biochemical dissection of β-amyloid in 1984, the" amyloid hypothesis" of Alzheimer's …
Genetics, functions, and clinical impact of presenilin-1 (PSEN1) gene
Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …
Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease
Presenilins play essential roles in memory formation, synaptic function, and neuronal
survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial …
survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial …
Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families
C Cruchaga, S Chakraverty, K Mayo, FLM Vallania… - PloS one, 2012 - journals.plos.org
Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked
to familial early onset forms of dementia. Mutation screening in these genes has been …
to familial early onset forms of dementia. Mutation screening in these genes has been …
Epidemiology of neurodegeneration
R Mayeux - Annual review of neuroscience, 2003 - annualreviews.org
▪ Abstract Alzheimer's disease, Parkinson's disease, and motor neuron disease share a
propensity to occur with increasing age and as either a sporadic or a familial disorder. A …
propensity to occur with increasing age and as either a sporadic or a familial disorder. A …
[HTML][HTML] Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of …
JS Goldman, SE Hahn, JW Catania… - Genetics in …, 2011 - Elsevier
Alzheimer disease is the most common cause of dementia. It occurs worldwide and affects
all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased …
all ethnic groups. The incidence of Alzheimer disease is increasing due, in part, to increased …
The genetics of Alzheimer's disease
Alzheimer's disease (AD) is a complex and heterogeneous neurodegenerative disorder,
classified as either early onset (under 65 years of age), or late onset (over 65 years of age) …
classified as either early onset (under 65 years of age), or late onset (over 65 years of age) …