The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

BACKGROUND: Besides transferrin iron, which represents the normal form of circulating
iron, non-transferrin bound iron (NTBI) has been identified in the plasma of patients with …

Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to
alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Although iron is essential for living organisms to survive, its reactive properties require strict
regulation in order to prevent toxic effects. Hepcidin, a liver produced peptide hormone, is …

The iron-regulatory hormone hepcidin is a 25–amino acid peptide that is synthesized in
hepatocytes. Hepcidin binds to the cellular iron export channel ferroportin and causes its …

Hereditary iron overload includes several disorders characterized by iron accumulation in
tissues, organs, or even single cells or subcellular compartments. They are determined by …

In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption
and macrophage release, causing anemia. Whether the mild proinflammatory state of aging …

Dysregulated production of hepcidin is implicated in anemia of inflammation, whereas
interleukin-6 (IL-6) is a major inducer of hepcidin production. Overproduction of IL-6 is …

Hepcidin is encoded as an 84 amino acid prepropeptide containing a typical N-terminal 24
amino acid endoplasmic reticulum targeting signal sequence, and a 35 amino acid …