Hepatic encephalopathy: effects of liver failure on brain function

V Felipo - Nature Reviews Neuroscience, 2013 - nature.com
Liver failure affects brain function, leading to neurological and psychiatric alterations; such
alterations are referred to as hepatic encephalopathy (HE). Early diagnosis of minimal HE …

Neurobiology of ammonia

V Felipo, RF Butterworth - Progress in neurobiology, 2002 - Elsevier
Hyperammonemia resulting from inherited urea cycle enzyme deficiencies or liver failure
results in severe central nervous system dysfunction including brain edema, convulsions …

Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the …

M Pascual, J Boix, V Felipo… - Journal of …, 2009 - Wiley Online Library
Adolescence is a developmental period which the risk of drug and alcohol abuse increases.
Since mesolimbic dopaminergic system undergoes developmental changes during …

Ammonia metabolism, the brain and fatigue; revisiting the link

DJ Wilkinson, NJ Smeeton, PW Watt - Progress in neurobiology, 2010 - Elsevier
This review addresses the ammonia fatigue theory in light of new evidence from exercise
and disease studies and aims to provide a view of the role of ammonia during exercise …

Hyperammonemia in hepatic encephalopathy

AR Jayakumar, MD Norenberg - Journal of clinical and experimental …, 2018 - Elsevier
The precise mechanism underlying the neurotoxicity of Hepatic Encephalopathy (HE) is
remains unclear. The dominant view has been that gut-derived nitrogenous toxins are not …

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

O Cauli, R Rodrigo, M Llansola, C Montoliu… - Metabolic Brain …, 2009 - Springer
Patients with hepatic encephalopathy (HE) may present different neurological alterations
including impaired cognitive function and altered motor activity and coordination. HE may …

Neurotransmitter receptor alterations in hepatic encephalopathy: a review

N Palomero-Gallagher, K Zilles - Archives of biochemistry and biophysics, 2013 - Elsevier
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome with symptoms
ranging from subtle neuropsychiatric and motor disturbances to deep coma and death, is …

Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy

M Llansola, C Montoliu, A Agusti… - Neurochemistry …, 2015 - Elsevier
The cognitive and motor alterations in hepatic encephalopathy (HE) are the final result of
altered neurotransmission and communication between neurons in neuronal networks and …

Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: therapeutical implications

P Monfort, O Cauli, C Montoliu, R Rodrigo… - Neurochemistry …, 2009 - Elsevier
Patients with liver diseases (eg cirrhosis) may present hepatic encephalopathy (HE), an
alteration in cerebral function which is a consequence of previous failure of liver function …

Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity

O Cauli, R Rodrigo, B Piedrafita… - Journal of …, 2009 - Wiley Online Library
Patients with hepatic encephalopathy show altered motor function, psychomotor slowing,
and hypokinesia, which are reproduced in rats with portacaval shunts (PCS). Increased …