Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Quantum dots (QDs) are semiconductor nanocrystals possessing unique optoelectrical
properties in that they can emit light energy of specific tunable wavelengths when excited by …

Ketone bodies are crucial intermediate metabolites widely associated with treating
metabolic diseases. Accumulating evidence suggests that ketone bodies may act as …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive decline.
Despite worldwide efforts to find a cure, no proper treatment has been developed yet, and …

It has been well recognized that intake of diets rich in saturated fats could result in
development of metabolic disorders such as type 2 diabetes mellitus, obesity and …

Background Diabetes has been recognized as a risk factor contributing to the incidence and
progression of Parkinson's disease (PD). Although several hypotheses suggest a number of …

Zebrafish has become a popular model to study many physiological and pathophysiological
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …

Brain delivery of nanoparticles and macromolecular drugs depends on blood-brain barrier
(BBB)-permeable carriers. In this study, we searched for cyclic heptapeptides facilitating …

Diabetes mellitus increases the risk of dementia, and evidence suggests hyperglycemia is a
key contributor to neurodegeneration. However, our understanding of diabetes-associated …

In current aging societies, diabetes mellitus and neurodegenerative diseases represented
by Alzheimer's disease are highly prevalent among adults, especially the elderly all over the …