The complement system in age-related macular degeneration

A Armento, M Ueffing, SJ Clark - Cellular and Molecular Life Sciences, 2021 - Springer
Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

Recent developments in age-related macular degeneration: a review

WM Al-Zamil, SA Yassin - Clinical interventions in aging, 2017 - Taylor & Francis
Background Visual impairment in elderly people is a considerable health problem that
significantly affects quality of life of millions worldwide. The magnitude of this issue is …

Age-related macular degeneration preferred practice pattern®

CJ Flaxel, RA Adelman, ST Bailey, A Fawzi, JI Lim… - …, 2020 - aaojournal.org
Background: Age-related macular degeneration is a leading cause of severe, irreversible
vision impairment in developed countries. The primary risk factors for the development of …

The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target

DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

JT Handa, C Bowes Rickman, AD Dick… - Nature …, 2019 - nature.com
Age-related macular degeneration (AMD) is the most common cause of blindness among
the elderly in the developed world. While treatment is effective for the neovascular or “wet” …

Age-related macular degeneration: pathophysiology, management, and future perspectives

R Flores, Â Carneiro, M Vieira, S Tenreiro… - Ophthalmologica, 2021 - karger.com
Among older adults, age-related macular degeneration (AMD) is a prevalent disabling
condition that begins as subtle visual disturbances and can progress to permanent loss of …

[HTML][HTML] Macular atrophy in the HARBOR study for neovascular age-related macular degeneration

SVR Sadda, LL Tuomi, B Ding, AE Fung, JJ Hopkins - Ophthalmology, 2018 - Elsevier
Purpose To evaluate macular atrophy (MA) presence in the 24-month HARBOR study
(NCT00891735) for neovascular age-related macular degeneration (AMD). Design Post hoc …

Carotenoids: potential allies of cardiovascular health?

AG Maria, R Graziano, DO Nicolantonio - Food & nutrition research, 2015 - Taylor & Francis
Carotenoids are a class of natural, fat-soluble pigments found principally in plants. They
have potential antioxidant biological properties because of their chemical structure and …

Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3

EY Chew, TE Clemons, JP SanGiovanni… - JAMA …, 2014 - jamanetwork.com
Importance The Age-Related Eye Disease Study (AREDS) formulation for the treatment of
age-related macular degeneration (AMD) contains vitamin C, vitamin E, beta carotene, and …

[HTML][HTML] Global burden of dry age-related macular degeneration: a targeted literature review

NM Schultz, S Bhardwaj, C Barclay, L Gaspar… - Clinical …, 2021 - Elsevier
Purpose Age-related macular degeneration (AMD) is a leading cause of blindness,
particularly in higher-income countries. Although dry AMD accounts for 85% to 90% of AMD …