Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety
profile in a wide range of animal models and human clinical trials. With the advent of …

Human papillomavirus (HPV) is the most common sexually transmitted virus in the world.
About 70% of cervical cancers are caused by the most oncogenic HPV genotypes of 16 and …

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

Epigenetics classically refers to the inheritable changes of hereditary information without
perturbing DNA sequences. Understanding mechanisms of how epigenetic factors …

Lung cancer stands as the primary contributor to cancer-related fatalities worldwide,
affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC) …

DNA holds genetic information in the nucleus of eukaryotic cells; and has three different
functions: replication, storage of hereditary information, and regulation of cell division. Most …

The achievement of animal cloning and subsequent development of cell reprogramming
technology are having a profound impact on our view of the mechanisms of aging in …

The integrity of chromosome ends, or telomeres, depends on myriad processes that must
balance the need to compact and protect the telomeric, G-rich DNA from detection as a …

The development of high-throughput methods has enabled the genome-wide identification
of putative regulatory elements in a wide variety of mammalian cells at an unprecedented …

Worldwide populations are aging with economic development as a result of public health
initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has …