The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

New neurons and glial cells are generated in an extensive germinal niche adjacent to the
walls of the lateral ventricles in the adult brain. The primary progenitors (B1 cells) have …

While a massive and progressive neuronal loss in specific areas such as the hippocampus
and cortex unequivocally underlies cognitive deterioration and memory loss in Alzheimer's …

Adult neurogenesis was first observed nearly 60 years ago, and it has since grown into an
important neurochemistry research field. Much recent research has focused on the treatment …

Summary Disrupted-in-schizophrenia 1 (DISC1), a susceptibility gene for major mental
illnesses, regulates multiple aspects of embryonic and adult neurogenesis. Here, we show …

Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …

Neuronal specification occurs at the periventricular surface of the embryonic central nervous
system. During early postnatal periods, radial glial cells in various ventricular zones of the …

Abstract The neuregulin 1 (NRG1) receptor, ErbB4, has been identified as a potential risk
gene for schizophrenia. HER4/ErbB4 is a receptor tyrosine kinase whose transcript …

The schizophrenia brain is differentiated from the normal brain by subtle changes, with
significant overlap in measures between normal and disease states. For the past 25 years …

Abstract Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with
essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg …