Highlights•Recent crystal structures reveal insights into ligand promiscuity within the POT
family.•Selectivity pockets play important roles in peptide recognition and …

Background Cellular uptake of small peptides is an important physiological process
mediated by the PTR family of proton-coupled peptide transporters. In bacteria peptides can …

An enigma in the field of peptide transport is the structural basis for ligand promiscuity, as
exemplified by PepT1, the mammalian plasma membrane peptide transporter. Here, we …

Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the
major facilitator superfamily that constitute the main route of entry for a wide range of dietary …

Mammals produce volatile odours that convey different types of societal information. In
Homo sapiens, this is now recognised as body odour, a key chemical component of which is …

Bacteria possess numerous peptide transporters for importing peptides as nutrients.
However, these peptide transporters are now consistently reported to play a role in the …

The uptake and elimination of beta-lactam antibiotics in the human body are facilitated by
the proton-coupled peptide transporters PepT1 (SLC15A1) and PepT2 (SLC15A2). The …

Inhibitors for membrane transporters have been shown to be indispensable as drugs and
tool compounds. The proton-dependent oligopeptide transporters PEPT1 and PEPT2 from …

Shikimic acid (SA) pathway is the common route used by bacteria, plants, fungi, algae, and
certain Apicomplexa parasites for the biosynthesis of aromatic amino acids and other …

Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS)
mediate the uptake of short di-and tripeptides in all phyla of life. POTs are thought to …