Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas
genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, and …

Abstract CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and
is required for multiple steps in telomere replication, including termination of G-strand …

Maintaining the structural integrity of genomic chromosomal DNA is an essential role of
cellular life and requires two important biological mechanisms: the DNA damage response …

Inflammation is an innate immune response to infection, and it is the main factor causing
bodily injury and other complications in the pathological process. Ginsenoside Rh4 (G-Rh4) …

Recent publications have presented research showing that WD repeat domain 4 (WDR4)
plays a significant role in various kinds of malignant tumours. However, the expression …

Background RAD51, a critical protein for DNA repairment, has been found to associate with
multiple cancer types, but, so far, a systematic pan-cancer analysis of RAD51 has not been …

Telomerase activation is required for malignant transformation. Recent advances in high‐
throughput technologies have enabled the generation of complex datasets, thus providing …

For high-dimensional expression data, most prognostic models perform feature selection
based on individual genes, which usually lead to unstable prognosis, and the identified risk …

Background: The tumor-associated endothelial cell (TAE) component plays a vital role in
tumor immunity. However, systematic tumor-associated endothelial-related gene …

Telomere dysfunction is one of the hallmarks of cancer, which puts telomere-associated
genes in a prominent position in oncology. The CTC1-STN1-TEN1 (CST) complex is vital for …