Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence

SZ Alshawwa, AA Kassem, RM Farid, SK Mostafa… - Pharmaceutics, 2022 - mdpi.com
There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …

The in vivo fate of polymeric micelles

Y Cai, J Qi, Y Lu, H He, W Wu - Advanced Drug Delivery Reviews, 2022 - Elsevier
This review aims to provide a systemic analysis of the in vivo, as well as subcellular, fate of
polymeric micelles (PMs), starting from the entry of PMs into the body. Few PMs are able to …

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Nanoparticle characterization: state of the art, challenges, and emerging technologies

EJ Cho, H Holback, KC Liu… - Molecular …, 2013 - ACS Publications
Nanoparticles have received enormous attention as a promising tool to enhance target-
specific drug delivery and diagnosis. Various in vitro and in vivo techniques are used to …

Current hurdles to the translation of nanomedicines from bench to the clinic

S Đorđević, MM Gonzalez, I Conejos-Sánchez… - Drug delivery and …, 2022 - Springer
The field of nanomedicine has significantly influenced research areas such as drug delivery,
diagnostics, theranostics, and regenerative medicine; however, the further development of …

FRET-based analysis on the structural stability of polymeric micelles: Another key attribute beyond PEG coverage and particle size affecting the blood clearance

C Guo, H Yuan, Y Yu, Z Gao, Y Zhang, T Yin… - Journal of Controlled …, 2023 - Elsevier
Various attributes of micelles, such as PEG density and particle size, are considered to be
related to blood clearance. The structural stability of micelles is another key attribute that will …

Are existing standard methods suitable for the evaluation of nanomedicines: some case studies

S Gioria, F Caputo, P Urbán, CM Maguire… - …, 2018 - Taylor & Francis
The use of nanotechnology in medical products has been demonstrated at laboratory scale,
and many resulting nanomedicines are in the translational phase toward clinical …

Micellar and structural stability of nanoscale amphiphilic polymers: implications for anti-atherosclerotic bioactivity

Y Zhang, Q Li, WJ Welsh, PV Moghe, KE Uhrich - Biomaterials, 2016 - Elsevier
Atherosclerosis, a leading cause of mortality in developed countries, is characterized by the
buildup of oxidized low-density lipoprotein (oxLDL) within the vascular intima, unregulated …

Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

N Raval, R Maheshwari, H Shukla, K Kalia… - Materials Science and …, 2021 - Elsevier
Polymeric micelles are a prevalent topic of research for the past decade, especially
concerning their fitting ability to deliver drug and diagnostic agents. This delivery system …

DNA nanotechnology enters cell membranes

S Huo, H Li, AJ Boersma, A Herrmann - Advanced Science, 2019 - Wiley Online Library
DNA is more than a carrier of genetic information: It is a highly versatile structural motif for
the assembly of nanostructures, giving rise to a wide range of functionalities. In this regard …