As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …

Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …

Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior
fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further …

Posterior fossa type A (PFA) ependymomas exhibit very low H3K27 methylation and express
high levels of EZHIP (Enhancer of Zeste Homologs Inhibitory Protein, also termed …

Developmentally regulated accessory subunits dictate PRC2 function. Here, we report the
crystal structures of a 120 kDa heterotetrameric complex consisting of Suz12, Rbbp4, Jarid2 …

The Polycomb group of proteins is required for the proper orchestration of gene expression
due to its role in maintaining transcriptional silencing. It is composed of several chromatin …

Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …

The Hippo pathway is dysregulated in many different cancers, but point mutations in the
pathway are rare. Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes …

Abstract The EZH2, EED, and SUZ12 genes encode proteins that comprise core
components of the polycomb repressive complex 2 (PRC2), an epigenetic “writer” with …

Endometrial stromal sarcomas (ESS) are a heterogeneous group of rare mesenchymal
cancers. Considerable knowledge has been gained in recent years about the molecular …