Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli

MRA Karam, M Habibi, S Bouzari - Molecular immunology, 2019 - Elsevier
Urinary tract infections (UTIs) are recognized as one of the most common infectious
diseases in the world that can be divided to different types. Uropathogenic Escherichia coli …

[HTML][HTML] Symposium review: The uterine microbiome associated with the development of uterine disease in dairy cows

KN Galvão, RC Bicalho, SJ Jeon - Journal of dairy science, 2019 - Elsevier
Until 2010, our knowledge of the uterine microbiome in cows that developed uterine disease
relied almost exclusively on culture-dependent studies and mostly included cows with …

Host–pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection

TJ Hannan, M Totsika, KJ Mansfield… - FEMS microbiology …, 2012 - academic.oup.com
Bladder infections affect millions of people yearly, and recurrent symptomatic infections
(cystitis) are very common. The rapid increase in infections caused by multidrug-resistant …

Drug and vaccine development for the treatment and prevention of urinary tract infections

VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …

How do bacteria know they are on a surface and regulate their response to an adhering state?

HJ Busscher, HC van der Mei - PLoS pathogens, 2012 - journals.plos.org
Bacteria adhere to virtually all natural and synthetic surfaces [1, 2]. Although there are a
number of different reasons as to why bacteria adhere to a surface, the summarizing answer …

Preventing urinary tract infection: progress toward an effective Escherichia coli vaccine

AR Brumbaugh, HLT Mobley - Expert review of vaccines, 2012 - Taylor & Francis
Uncomplicated urinary tract infections (UTIs) are common, with nearly half of all women
experiencing at least one UTI in their lifetime. This high frequency of infection results in huge …

Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets

MM Sauer, RP Jakob, T Luber… - Journal of the …, 2018 - ACS Publications
Multivalent carbohydrate–lectin interactions at host–pathogen interfaces play a crucial role
in the establishment of infections. Although competitive antagonists that prevent pathogen …

Carbohydrate–macrocycle conjugates for biomedical applications

F Yin, JJ Li, B Shi, K Zhang, XL Li, KR Wang… - Materials Chemistry …, 2023 - pubs.rsc.org
Carbohydrates are of great importance in a variety of biological processes, including but not
limited to, energy production, energy storage, protein recognition, immune response, and …

Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function

DG Thanassi, JB Bliska… - FEMS microbiology …, 2012 - academic.oup.com
Gram-negative bacteria express a wide variety of organelles on their cell surface. These
surface structures may be the end products of secretion systems, such as the hair-like fibers …