Virtual clinical trials in medical imaging: a review

E Abadi, WP Segars, BMW Tsui… - Journal of Medical …, 2020 - spiedigitallibrary.org
The accelerating complexity and variety of medical imaging devices and methods have
outpaced the ability to evaluate and optimize their design and clinical use. This is a …

A scanner-specific framework for simulating CT images with tube current modulation

G Jadick, E Abadi, B Harrawood… - Physics in Medicine …, 2021 - iopscience.iop.org
Although tube current modulation (TCM) is routinely implemented in modern computed
tomography (CT) scans, no existing CT simulator is capable of generating realistic images …

Virtual imaging trials for coronavirus disease (COVID-19)

E Abadi, W Paul Segars, H Chalian… - American Journal of …, 2021 - Am Roentgen Ray Soc
OBJECTIVE. The virtual imaging trial is a unique framework that can greatly facilitate the
assessment and optimization of imaging methods by emulating the imaging experiment …

Emphysema quantifications with CT scan: Assessing the effects of acquisition protocols and imaging parameters using virtual imaging trials

E Abadi, G Jadick, DA Lynch, WP Segars, E Samei - Chest, 2023 - Elsevier
Background CT scan has notable potential to quantify the severity and progression of
emphysema in patients. Such quantification should ideally reflect the true attributes and …

Task‐based validation and application of a scanner‐specific CT simulator using an anthropomorphic phantom

SS Shankar, N Felice, EA Hoffman, J Atha… - Medical …, 2022 - Wiley Online Library
Background Quantitative analysis of computed tomography (CT) images traditionally utilizes
real patient data that can pose challenges with replicability, efficiency, and radiation …

Photon-counting CT versus conventional CT for COPD quantifications: intra-scanner optimization and inter-scanner assessments using virtual imaging trials

S Sotoudeh-Paima, WP Segars… - … 2022: Physics of …, 2022 - spiedigitallibrary.org
CT imaging has proved to be an effective tool in evaluating COPD patients. The
development of photon-counting detectors has offered better spatial resolution and reduced …

A GPU-accelerated framework for rapid estimation of scanner-specific scatter in CT for virtual imaging trials

S Sharma, E Abadi, A Kapadia… - Physics in Medicine & …, 2021 - iopscience.iop.org
Virtual imaging trials (VITs), defined as the process of conducting clinical imaging trials
using computer simulations, offer a time-and cost-effective alternative to traditional imaging …

Development and clinical applications of a virtual imaging framework for optimizing photon-counting CT

E Abadi, C McCabe, B Harrawood… - … 2022: Physics of …, 2022 - spiedigitallibrary.org
The purpose of this study was to develop a virtual imaging framework that simulates a new
photon-counting CT (PCCT) system (NAEOTOM Alpha, Siemens). The PCCT simulator was …

Deep silicon photon-counting CT: A first simulation-based study for assessing perceptual benefits across diverse anatomies

S Sharma, D Pal, E Abadi, P Segars, J Hsieh… - European Journal of …, 2024 - Elsevier
Objectives To assess perceptual benefits provided by the improved spatial resolution and
noise performance of deep silicon photon-counting CT (Si-PCCT) over conventional energy …

A systematic assessment and optimization of photon‐counting CT for lung density quantifications

S Sotoudeh‐Paima, WP Segars, D Ghosh… - Medical …, 2024 - Wiley Online Library
Background Photon‐counting computed tomography (PCCT) has recently emerged into
clinical use; however, its optimum imaging protocols and added benefits remains unknown …