Recombinant ASF live attenuated virus strains as experimental vaccine candidates

DP Gladue, MV Borca - Viruses, 2022 - mdpi.com
African swine fever (ASF) is causing a pandemic affecting swine in a large geographical
area of the Eastern Hemisphere, from Central Europe to East and Southeast Asia, and …

MGF360-9L is a major virulence factor associated with the African swine fever virus by antagonizing the JAK/STAT signaling pathway

K Zhang, B Yang, C Shen, T Zhang, Y Hao, D Zhang… - MBio, 2022 - Am Soc Microbiol
African swine fever (ASF)—an aggressive infectious disease caused by the African swine
fever virus (ASFV)—is significantly unfavorable for swine production. ASFV has a complex …

Deletion of the A137R gene from the pandemic strain of African swine fever virus attenuates the strain and offers protection against the virulent pandemic virus

DP Gladue, E Ramirez-Medina, E Vuono… - Journal of …, 2021 - Am Soc Microbiol
African swine fever virus (ASFV) is causing a devastating pandemic in domestic and wild
swine within an extended geographical area from Central Europe to East Asia, resulting in …

African swine fever virus E120R protein inhibits interferon beta production by interacting with IRF3 to block its activation

H Liu, Z Zhu, T Feng, Z Ma, Q Xue, P Wu, P Li… - Journal of …, 2021 - Am Soc Microbiol
African swine fever is a devastating disease of swine caused by African swine fever virus
(ASFV). The pathogenesis of the disease remains largely unknown, leaving the spread of …

A cell culture-adapted vaccine virus against the current African swine fever virus pandemic strain

MV Borca, A Rai, E Ramirez-Medina, E Silva… - Journal of …, 2021 - Am Soc Microbiol
African swine fever virus (ASFV) causes a virulent, deadly infection in wild and domestic
swine and is currently causing a pandemic covering a contiguous geographical area from …

Attenuated African swine fever viruses and the live vaccine candidates: a comprehensive review

J Fan, H Yu, F Miao, J Ke, R Hu - Microbiology Spectrum, 2024 - journals.asm.org
The African swine fever virus (ASFV) is spreading worldwide and causing huge economic
losses to the global pig industry. The ASFV genome is 170–193 kb in length, contains …

Adaptation of African swine fever virus to HEK293T cells

T Wang, L Wang, Y Han, L Pan, J Yang… - Transboundary and …, 2021 - Wiley Online Library
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious
disease with high morbidity and mortality in domestic pigs. Although adaptation of ASFV to …

Deletion of African swine fever virus histone-like protein, A104R from the Georgia isolate drastically reduces virus virulence in domestic pigs

E Ramirez-Medina, EA Vuono, S Pruitt, A Rai… - Viruses, 2022 - mdpi.com
African swine fever virus (ASFV) is the etiological agent of a frequently lethal disease, ASF,
affecting domestic and wild swine. Currently, ASF is causing a pandemic affecting pig …

Deletion of the H240R Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine

E Ramirez-Medina, A Rai, N Espinoza, A Valladares… - Viruses, 2023 - mdpi.com
African swine fever (ASF) is a highly contagious disease that affects wild and domestic
swine. Currently, the disease is present as a pandemic affecting pork production in Eurasia …

Evaluation of the Function of the ASFV KP177R Gene, Encoding for Structural Protein p22, in the Process of Virus Replication and in Swine Virulence

EA Vuono, E Ramirez-Medina, S Pruitt, A Rai… - Viruses, 2021 - mdpi.com
African swine fever virus (ASFV) causes a devastating disease of swine that has caused
outbreaks in Central Europe since 2007, spreading into Asia in 2018. ASFV is a large …