Defective mitochondrial quality control during dengue infection contributes to disease pathogenesis
Mitochondrial fitness is governed by mitochondrial quality control pathways comprising
mitochondrial dynamics and mitochondrial-selective autophagy (mitophagy). Disruption of …
mitochondrial dynamics and mitochondrial-selective autophagy (mitophagy). Disruption of …
Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that can have devastating health
consequences. The developmental and neurological effects of a ZIKV infection arise in part …
consequences. The developmental and neurological effects of a ZIKV infection arise in part …
The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype
A Schollmeier, M Basic, M Glitscher, E Hildt - Journal of Virology, 2024 - Am Soc Microbiol
Chronic hepatitis B virus (HBV) infections are strongly associated with liver cirrhosis,
inflammation, and hepatocellular carcinoma. In this context, the viral HBx protein is …
inflammation, and hepatocellular carcinoma. In this context, the viral HBx protein is …
[HTML][HTML] Zika Virus NS1 Drives Tunneling Nanotube Formation for Mitochondrial Transfer, Enhanced Survival, Interferon Evasion, and Stealth Transmission in …
Zika virus (ZIKV) infection continues to pose a significant public health concern due to
limited available preventive measures and treatments. ZIKV is unique among flaviviruses in …
limited available preventive measures and treatments. ZIKV is unique among flaviviruses in …
PKR-mediated stress response enhances dengue and Zika virus replication
The mechanisms by which flaviviruses use non-canonical translation to support their
replication in host cells are largely unknown. Here, we investigated how the integrated …
replication in host cells are largely unknown. Here, we investigated how the integrated …
Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation
B Tejera-Hernández, DE Goodman… - Journal of …, 2022 - Am Soc Microbiol
Protein kinase R (PKR) is a cellular kinase involved in the antiviral response. The
inactivation or inhibition of this protein is a conserved activity in DNA and RNA virus …
inactivation or inhibition of this protein is a conserved activity in DNA and RNA virus …