The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation

L Moretti, J Stalfort, TH Barker, D Abebayehu - Journal of Biological …, 2022 - ASBMB
Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

J Xue, Z Zhao, L Zhang, L Xue, S Shen, Y Wen… - Nature …, 2017 - nature.com
Cell-mediated drug-delivery systems have received considerable attention for their
enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the …

New perspectives on the origins and heterogeneity of mast cells

AL St. John, APS Rathore, F Ginhoux - Nature Reviews Immunology, 2023 - nature.com
Mast cells are immune cells of the haematopoietic lineage that are now thought to have
multifaceted functions during homeostasis and in various disease states. Furthermore, while …

Mast cell biology at molecular level: a comprehensive review

D Elieh Ali Komi, S Wöhrl, L Bielory - Clinical reviews in allergy & …, 2020 - Springer
Mast cells (MCs) are portions of the innate and adaptive immune system derived from bone
marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype …

Leukocyte migration into inflamed tissues

S Nourshargh, R Alon - Immunity, 2014 - cell.com
Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

Mast cell: a multi-functional master cell

M Krystel-Whittemore, KN Dileepan… - Frontiers in …, 2016 - frontiersin.org
Mast cells are immune cells of the myeloid lineage and are present in connective tissues
throughout the body. The activation and degranulation of mast cells significantly modulates …

Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation

JW Myerson, PN Patel, KM Rubey, ME Zamora… - Nature …, 2022 - nature.com
This study shows that the supramolecular arrangement of proteins in nanoparticle structures
predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We …

The chemokine system in innate immunity

CL Sokol, AD Luster - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Chemokines are chemotactic cytokines that control the migration and positioning of immune
cells in tissues and are critical for the function of the innate immune system. Chemokines …

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

M Li, S Li, H Zhou, X Tang, Y Wu, W Jiang… - Nature …, 2020 - nature.com
The efficacy of nano-mediated drug delivery has been impeded by multiple biological
barriers such as the mononuclear phagocyte system (MPS), as well as vascular and …