MDM4 is a homologue of MDM2, serving cooperatively as the negative regulator of tumor
suppressor p53. Under the shadow of MDM2 inhibitors, limited efforts had been put into the …

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …

The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor
suppressor p53 and has been implicated in the initiation and progression of human cancers …

Glioblastoma is the most common primary brain tumor in adults with poor overall outcome
and 5-year survival of less than 5%. Treatment has not changed much in the last decade or …

Abstract Mouse double minute 2 (MDM2), an E3 ubiquitin ligase and the primary negative
regulator of the tumor suppressor p53, cooperates with its structural homolog MDM4/MDMX …

Autoinhibition of p53 binding to MDMX requires two short-linear motifs (SLiMs) containing
adjacent tryptophan (WW) and tryptophan-phenylalanine (WF) residues. NMR spectroscopy …

The p53 tumor suppressor protein plays an important role in physiological and pathological
processes. MDM2 and its homolog MDMX are the most important negative regulators of p53 …

Murine double minute X (MDMX) is an oncoprotein that mainly has a negative regulatory
effect on the tumor suppressor p53 to induce tumorigenesis. As MDMX is highly expressed …

The rare earth metal Gd (III), Yb (III), Lu (III), Eu (III), Tb (III) and Ho (III) complexes 1–6 with 2-
((2-(pyridin-2-yl) hydrazono) methyl) quinolin-8-ol (HL) as ligands were synthesized. The in …

Objective. This study aimed to observe the effect of hesperidin on the apoptosis,
proliferation, and invasion of non‐small‐cell lung cancer, as well as to explore the possible …