[HTML][HTML] SARS-CoV-2 Omicron variant: recent progress and future perspectives

Y Fan, X Li, L Zhang, S Wan, L Zhang… - Signal transduction and …, 2022 - nature.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been
a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of …

SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”

BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

B Meng, A Abdullahi, IATM Ferreira, N Goonawardane… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

FA Lempp, LB Soriaga, M Montiel-Ruiz, F Benigni… - Nature, 2021 - nature.com
Abstract SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—
relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically …

[HTML][HTML] Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

L Braga, H Ali, I Secco, E Chiavacci, G Neves… - Nature, 2021 - nature.com
COVID-19 is a disease with unique characteristics that include lung thrombosis, frequent
diarrhoea, abnormal activation of the inflammatory response and rapid deterioration of lung …

Persistent endotheliopathy in the pathogenesis of long COVID syndrome

H Fogarty, L Townsend, H Morrin… - … of thrombosis and …, 2021 - Wiley Online Library
Background Persistent symptoms including breathlessness, fatigue, and decreased exercise
tolerance have been reported in patients after acute SARS‐CoV‐2 infection. The biological …

[HTML][HTML] Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B. 1.1. 7

B Meng, SA Kemp, G Papa, R Datir, IATM Ferreira… - Cell reports, 2021 - cell.com
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70
in multiple independent lineages, often occurring after acquisition of receptor binding motif …

SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …

SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation

MM Rajah, M Hubert, E Bishop, N Saunders… - The EMBO …, 2021 - embopress.org
Severe COVID‐19 is characterized by lung abnormalities, including the presence of
syncytial pneumocytes. Syncytia form when SARS‐CoV‐2 spike protein expressed on the …

Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants

C Li, J Huang, Y Yu, Z Wan, MC Chiu… - Proceedings of the …, 2023 - National Acad Sciences
The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …