Tuberculosis: pathogenesis, current treatment regimens and new drug targets
SSR Alsayed, H Gunosewoyo - International journal of molecular …, 2023 - mdpi.com
Mycobacterium tuberculosis (M. tb), the causative agent of TB, is a recalcitrant pathogen that
is rife around the world, latently infecting approximately a quarter of the worldwide …
is rife around the world, latently infecting approximately a quarter of the worldwide …
Tuberculosis drug discovery: challenges and new horizons
GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
Twenty years of bacterial genome sequencing
Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus
influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades …
influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades …
Crystal structures of membrane transporter MmpL3, an anti-TB drug target
Despite intensive efforts to discover highly effective treatments to eradicate tuberculosis
(TB), it remains as a major threat to global human health. For this reason, new TB drugs …
(TB), it remains as a major threat to global human health. For this reason, new TB drugs …
Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target
KA Abrahams, GS Besra - Parasitology, 2018 - cambridge.org
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …
as a global health emergency as promoted by the World Health Organization. Over 1 million …
[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …
incremental scientific work and all positive socio-political engagements, are steps taken in …
The mycobacterial cell envelope—lipids
M Jackson - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …
MmpL3 is the flippase for mycolic acids in mycobacteria
Z Xu, VA Meshcheryakov, G Poce… - Proceedings of the …, 2017 - National Acad Sciences
The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic
acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to …
acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to …
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
W Li, A Upadhyay, FL Fontes, EJ North… - Antimicrobial agents …, 2014 - Am Soc Microbiol
ABSTRACT MmpL3, a resistance-nodulation-division (RND) superfamily transporter, has
been implicated in the formation of the outer membrane of Mycobacterium tuberculosis; …
been implicated in the formation of the outer membrane of Mycobacterium tuberculosis; …
Structural and functional diversity of resistance–nodulation–cell division transporters
Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …
becoming increasingly difficult to eliminate. While significant effort has gone into the …