The 'EF-hand'Ca2+-binding motif plays an essential role in eukaryotic cellular signalling,
and the proteins containing this motif constitute a large and functionally diverse family. The …

The calcium binding proteins of the EF-hand super-family are involved in the regulation of all
aspects of cell function. These proteins exhibit a great diversity of composition, structure …

NADPH oxidase 5 (NOX5) is a homologue of the gp91 phox subunit of the phagocyte
NADPH oxidase. NOX5 is expressed in lymphoid organs and testis and distinguished from …

Candida albicans is both a commensal and an opportunistic fungal pathogen. Invading
hyphae of C. albicans secrete candidalysin, a pore-forming peptide toxin. To prevent cell …

▪ Abstract All microorganisms must adapt to the pH of their environment. One aspect of this
adaptation, particularly important for organisms that grow over a wide pH range, is the ability …

Penta-EF-hand (PEF) proteins comprise a family of Ca2+-binding proteins that have five
repetitive EF-hand motifs. Among the eight α-helices (α1–α8), α4 and α7 link EF2–EF3 and …

Calpains are Ca 2+-regulated proteolytic enzymes that are involved in a variety of biological
phenomena. Calpains process substrates by limited proteolysis to modulate various protein …

Apoptosis linked Gene-2 (ALG-2) is a multifunctional intracellular Ca2+ sensor and the
archetypal member of the penta-EF hand protein family. ALG-2 functions in the repair of …

Calcium ions regulate many cellular processes and have important structural roles in living
organisms. Despite the great variety of calcium-binding proteins (CaBPs), many of them …

The Ca2+-dependent cysteine protease calpain along with its endogenous inhibitor
calpastatin is widely distributed. The interactions between calpain and calpastatin have …