Purpose This paper briefly reviews current explanations for corneal transparency and uses a
well-developed model to try to explain the increased light scattering either accompanying …

The corneal epithelium serves as a barrier and contributes to the maintenance of corneal
transparency and rigidity. In most instances, corneal epithelial defects caused by simple …

Lens epithelial cells undergo epithelial-mesenchymal transition (EMT) after injury as in
cataract extraction, leading to fibrosis of the lens capsule. Fibrosis of the anterior capsule …

purpose. Gene targeted lumican-null mutants (lum tm1sc/lum tm1sc) have cloudy corneas
with abnormally thick collagen fibrils. The purpose of the present study was to analyze the …

Severe corneal injuries often result in permanent vision loss and remain a clinical challenge.
Human bone marrow-derived mesenchymal stem cells (MSCs) and their secreted factors …

Corneal scarring from trauma and inflammation disrupts vision for millions worldwide, but
corneal transplantation, the primary therapy for corneal blindness, is unavailable to many …

Wound healing is a tissue regeneration process which is regulated by a complex interaction
of multiple growth factors, primarily transforming growth factor-β1 (TGF-β1). The natural …

Decorin and biglycan are class I small leucine-rich proteoglycans (SLRPs) involved in
regulation of collagen fibril and matrix assembly. We hypothesize that tissue-specific matrix …

Lumican and fibromodulin regulate the assembly of collagens into higher order fibrils in
connective tissues. Here, we show that mice deficient in both of these proteoglycans …

Extracellular matrix (ECM) remodeling has been associated with chronic lung diseases.
However, information about specific age-associated differences in lung ECM is currently …