Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Carbonic anhydrases (CAs), a group of ubiquitously expressed metalloenzymes, are
involved in numerous physiological and pathological processes, including …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread enzymes in all organisms,
catalyzing CO2 hydration to bicarbonate and protons. Their inhibition is exploited clinically …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are zinc enzymes acting as efficient catalysts for the
reversible hydration of carbon dioxide to bicarbonate. 16 different α-CA isoforms were …

The X-ray crystal structure of the adduct between the zinc metalloenzyme carbonic
anhydrase II (CA, EC 4.2. 1.1) with the recently discovered natural product coumarin …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are widespread metalloenzymes all over the
phylogenetic tree, with at least 4 distinct gene families encoding for them. At least 16 …

Coumarin derivatives were recently shown to constitute a totally new class of inhibitors of the
zinc metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1), being hydrolyzed within the CA …

Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …