Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence
The survival of the human malaria parasite Plasmodium falciparum under the
physiologically distinct environments associated with their development in the cold-blooded …
physiologically distinct environments associated with their development in the cold-blooded …
The Plasmodium falciparum exported J domain proteins fine-tune human and malarial Hsp70s: pathological exploitation of proteostasis machinery
Cellular proteostasis requires a network of molecular chaperones and co-chaperones,
which facilitate the correct folding and assembly of other proteins, or the degradation of …
which facilitate the correct folding and assembly of other proteins, or the degradation of …
In silico identification of modulators of J domain protein-Hsp70 interactions in Plasmodium falciparum: a drug repurposing strategy against malaria
Plasmodium falciparum is a unicellular, intracellular protozoan parasite, and the causative
agent of malaria in humans, a deadly vector borne infectious disease. A key phase of …
agent of malaria in humans, a deadly vector borne infectious disease. A key phase of …
Theoretical studies of Thiazolyl-Pyrazoline derivatives as promising drugs against malaria by QSAR modelling combined with molecular docking and molecular …
We investigate thiazolyl-pyrazoline derivatives as promising drugs for the anti-malarial.
Protein kinase G is a primary target for treating malaria due to its essential role in …
Protein kinase G is a primary target for treating malaria due to its essential role in …
Proteostasis is a key driver of the pathogenesis in Apicomplexa
P Mitra, AS Deshmukh - Biochimica et Biophysica Acta (BBA)-Molecular …, 2024 - Elsevier
Proteostasis, including protein folding mediated by molecular chaperones, protein
degradation, and stress response pathways in organelles like ER (unfolded protein …
degradation, and stress response pathways in organelles like ER (unfolded protein …
Plasmodium falciparum Molecular Chaperones: Guardians of the Malaria Parasite Proteome and Renovators of the Host Proteome
GL Blatch - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Plasmodium falciparum is a unicellular protozoan parasite and causative agent of the most
severe form of malaria in humans. The malaria parasite has had to develop sophisticated …
severe form of malaria in humans. The malaria parasite has had to develop sophisticated …
Structure-and ligand-based drug design methods for the modeling of antimalarial agents: a review of updates from 2012 onwards
VK Vyas, S Bhati, S Patel, M Ghate - Journal of Biomolecular …, 2022 - Taylor & Francis
Malaria still persists as one of the deadliest infectious disease having a huge morbidity and
mortality affecting the higher population of the world. Structure and ligand-based drug …
mortality affecting the higher population of the world. Structure and ligand-based drug …
Exported J domain proteins of the human malaria parasite
The heat shock protein 40 (Hsp40) family, also called J domain proteins (JDPs), regulate
their Hsp70 partners by ensuring that they are engaging the right substrate at the right time …
their Hsp70 partners by ensuring that they are engaging the right substrate at the right time …
Protein prenylation and Hsp40 in thermotolerance of Plasmodium falciparum malaria parasites
ES Mathews, AJ Jezewski, AR Odom John - Mbio, 2021 - Am Soc Microbiol
During its complex life cycle, the malaria parasite survives dramatic environmental stresses,
including large temperature shifts. Protein prenylation is required during asexual replication …
including large temperature shifts. Protein prenylation is required during asexual replication …
Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
Plasmodium falciparum is responsible for the most severe and deadliest human malaria
infection. The most serious complication of this infection is cerebral malaria. Among the …
infection. The most serious complication of this infection is cerebral malaria. Among the …