Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …

The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex
pathophysiological microenvironments at the injury site and the limited regenerative …

The concept of cognitive reserve was born to account for the disjunction between the
objective extent of brain damage in pathology and its clinical and intellectual outcome. The …

Cell-based therapies hold great promise for brain repair after stroke. While accumulating
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …

Polypeptides obtained from the ring-opening polymerization of N-carboxyanhydrides, as the
synthetic analogues of natural proteins, have drawn broad interests during the recent three …

Central nervous system (CNS) lesions become surrounded by neuroprotective borders of
newly proliferated reactive astrocytes; however, fundamental features of these cells are …

Using cell grafting to direct glia-based repair mechanisms in adult CNS injuries represents a
potential therapeutic strategy for supporting functional neural parenchymal repair. However …

Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk
between grafted cells and host tissue is largely unknown. Here, we take a step toward …

Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in
specific types of glial cells in the nervous system. The expression of GFAP is highly …