Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

The skeletal muscle is the largest organ in the body and secretes circulating factors,
including myokines, which are involved in various cellular signaling processes. Skeletal …

Mitochondrial remodeling is dysregulated in metabolic diseases but the underlying
mechanism is not fully understood. We report here that BDNF (brain derived neurotrophic …

Exercise has multiple beneficial effects on health including decreasing the risk of
neurodegenerative diseases. Such effects are thought to be mediated (at least in part) by …

Accumulating evidence supports that physical exercise (EX) is the most effective non-
pharmacological strategy to improve brain health. EX prevents cognitive decline associated …

Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …

Endocrine mechanisms have been largely associated with metabolic control and tissue
cross talk in mammals. Classically, myokines comprise a class of signaling proteins …

Brain-derived neurotrophic factor (BDNF) promotes the survival and functioning of neurons
in the central nervous system and contributes to proper functioning of many non-neural …

Aging causes degenerative changes such as epigenetic changes and mitochondrial
dysfunction in skeletal muscle. Exercise can upregulate muscle mitochondrial homeostasis …

Brain-derived neurotrophic factor (BDNF) represents one of the most widely studied
neurotrophins because of the many mechanisms in which it is involved. Among these, a …