The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master
regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory …

Endometriosis, a common cause of pelvic pain and female infertility, depends on the growth
of vascularized endometrial tissue at ectopic sites. Endometrial fragments reach the …

Hypoxia and hypoxia signalling through the transcription factor hypoxia inducible factor-1
(HIF-1), play an important role in normal tissue repair processes. Tissue injury generally …

The hypoxia-inducible transcription factors HIF-1 and HIF-2 mediate key cellular adaptions
to hypoxia and contribute to renal homeostasis and pathophysiology; however, little is …

In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the
wound. These patients might benefit from regenerative medicine or the implantation of a …

Infarction occurs when myocardial perfusion is interrupted for prolonged periods of time.
Short episodes of ischemia and reperfusion protect against tissue injury when the heart is …

More effective therapeutic strategies for the prevention and treatment of acute kidney injury
(AKI) are needed to improve the high morbidity and mortality associated with this frequently …

Abstract microRNAs (miRNAs) are small noncoding RNA molecules which play pivotal roles
in wound healing. The increased expression of certain genes and expression of some …