Mammalian arginine metabolism is complex due to the expression of multiple enzymes that
utilize arginine as substrate and to interactions or competition between specific enzymes …

Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in
the regulation of numerous vital biological functions, contributes to the development and …

Background & aims This position paper summarizes theoretical and practical aspects of the
monitoring of artificial nutrition and metabolism in critically ill patients, thereby completing …

Metabolome reflects the interplay of genome and exposome at molecular level and thus can
provide deep insights into the pathogenesis of a complex disease like major depression. To …

Frailty is a geriatric syndrome that predicts disability, morbidity and mortality in the elderly.
Poor nutritional status is one of the main risk factors for frailty. Macronutrients and …

Despite improvement in clinical management, allogeneic hematopoietic stem cell
transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to …

L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric
oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is …

Supplemental arginine has shown promise as a safe therapeutic option to improve
endogenous nitric oxide (NO) regulation in cardiovascular diseases associated with …

Background Heart failure with preserved ejection fraction (HFpEF) and HF with reduced
ejection fraction (HFrEF) are associated with metabolic derangements, which may have …

Aggravation of Exercise-Induced Intestinal Injury by Ibuprofen in Athletes Page 1 Aggravation of
Exercise-Induced Intestinal Injury by Ibuprofen in Athletes KIM VAN WIJCK1,2, KAATJE …