Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is
predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial …

Pathological cardiac fibrosis is a common feature in multiple cardiovascular diseases that
contributes to the occurrence of heart failure and life-threatening arrhythmias. Our previous …

Hypoxic tumor microenvironment (TME) plays critical roles in induction of cancer stem cell-
like phenotype in breast cancer and contribute to chemoresistance. However, the …

The unfolded protein response (UPR) is a highly conserved molecular machinery, which
protects the cells against a diverse variety of stimuli. Activation of this element has been …

The immunoglobulin heavy chain binding protein (BiP), also referred to as 78-kDa glucose-
regulated protein (GRP78), is a pivotal endoplasmic reticulum (ER) chaperone which …

Endoplasmic reticulum (ER) stress induction of cell death is implicated in cardiovascular
diseases. Sustained activation of ER-stress induces the unfolded protein response (UPR) …

T-2 toxin is a highly toxic trichothecene that can induce toxic effects in a variety of organs
and tissues, but the pathogenesis of its nephrotoxicity has not been elucidated. In this study …

Cardiovascular disease is the leading cause of death worldwide. Despite overwhelming
socioeconomic impact and mounting clinical needs, our understanding of the underlying …

Oxidative stress and cardiomyocyte apoptosis contributed to the progression of doxorubicin
(Dox)-induced cardiotoxicity. Recent studies identified microRNA-22 (miR-22) as a cardiac …

The integrity of the proteome in cardiac myocytes is critical for robust heart function.
Proteome integrity in all cells is managed by protein homeostasis or proteostasis, which …