PARP inhibitor resistance: the underlying mechanisms and clinical implications
Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …
PARP-1 and its associated nucleases in DNA damage response
Abstract Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia
Summary N 6-Methyladenosine (m 6 A) modification and its modulators play critical roles
and show promise as therapeutic targets in human cancers, including acute myeloid …
and show promise as therapeutic targets in human cancers, including acute myeloid …
[HTML][HTML] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
Replication fork stability confers chemoresistance in BRCA-deficient cells
A Ray Chaudhuri, E Callen, X Ding, E Gogola… - Nature, 2016 - nature.com
Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-
strand breaks by homologous recombination and consequently are hypersensitive to DNA …
strand breaks by homologous recombination and consequently are hypersensitive to DNA …
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
Abstract Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
[HTML][HTML] Exploiting replication gaps for cancer therapy
Defects in DNA double-strand break repair are thought to render BRCA1 or BRCA2 (BRCA)
mutant tumors selectively sensitive to PARP inhibitors (PARPis). Challenging this …
mutant tumors selectively sensitive to PARP inhibitors (PARPis). Challenging this …
Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
T Thakar, W Leung, CM Nicolae, KE Clements… - Nature …, 2020 - nature.com
Upon genotoxic stress, PCNA ubiquitination allows for replication of damaged DNA by
recruiting lesion-bypass DNA polymerases. However, PCNA is also ubiquitinated during …
recruiting lesion-bypass DNA polymerases. However, PCNA is also ubiquitinated during …
Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases
L Zheng, Y Meng, JL Campbell… - Nucleic acids research, 2020 - academic.oup.com
DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …
CtIP-mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress
Protecting stalled DNA replication forks from degradation by promiscuous nucleases is
essential to prevent genomic instability, a major driving force of tumorigenesis. Several …
essential to prevent genomic instability, a major driving force of tumorigenesis. Several …