Purpose: This article reviews the recent advances in understanding of the fundamental
properties of circadian rhythms and discusses the clinical features, diagnosis, and treatment …

Sleep is a complex, highly regulated process essential for human health and wellbeing.
Increasingly, sleep–wake disturbance has been implicated in the pathogenesis of chronic …

Adropin is a peptide hormone, which plays a role in energy homeostasis and controls
glucose and fatty acid metabolism. Its levels correlate with changes in carbohydrate‐lipid …

A considerable proportion of patients with cirrhosis exhibit insomnia, delayed sleep habits,
and excessive daytime sleepiness. These have been variously attributed to hepatic …

Background & Aims Sleep disturbances are common in patients with cirrhosis, but their
determinants and effects on health-related quality of life are not well-understood. We …

Sleep–wake disturbances are common in liver cirrhosis and associated with impaired
quality of life. The most common abnormalities are insomnia (difficulties falling asleep and …

Sleep disturbance is a common feature of chronic liver disease (CLD) with impact on health-
related quality of life; 60–80% of patients with CLD report subjective poor sleep; frequent …

Fibrosis is characterized by fibroblast proliferation and fibroblast differentiation into
myofibroblasts, which generate a relaxation-free contraction mechanism associated with …

OBJECTIVES: Plasma melatonin profile abnormalities have been described in patients with
cirrhosis and generally attributed to impaired hepatic melatonin metabolism. The possibility …

Patients with liver cirrhosis often exhibit sleep–wake abnormalities, which are, at least to
some extent, circadian in origin. A relatively novel non-pharmacological approach to …