Balanced mRNA isoform diversity and abundance are spatially and temporally regulated
throughout cellular differentiation. The proportion of expressed isoforms contributes to cell …

Living organisms are multiscale complex systems that have evolved high degrees of
multifunctionality and redundancy in the structure–function relationship. A number of factors …

Background Recent genome-wide association studies on major depressive disorder (MDD)
have indicated the involvement of LRFN5 and OLFM4; however, the expression levels and …

Ionotropic glutamate receptors (iGluRs) play key roles for signaling in the central nervous
system. Alternative splicing and RNA editing are well-known mechanisms to increase iGluR …

In amyotrophic lateral sclerosis (ALS), TAR DNA-binding protein 43 (TDP-43), which is
encoded by TARDBP, forms aggregates in the motor cortex. This aggregate formation may …

Proper expression of odor receptor genes is critical for the function of olfactory systems. In
this study, we identified exitrons (exonic introns) in four of the 39 Odorant receptor (Or) …

The distance between Ca V 2.1 voltage-gated Ca 2+ channels and the Ca 2+ sensor
responsible for vesicle release at presynaptic terminals is critical for determining synaptic …

Opiate/opioid use disorder (OUD) is a chronic relapsing brain disorder that has increased in
prevalence in the last two decades in the United States. Understanding the molecular …

Creating long-lasting memories requires learning-induced changes in gene expression,
which are impacted by epigenetic modifications of DNA and associated histone proteins …

Episodic ataxia type 2 (EA2) is an autosomal dominant neurological disorder characterized
by paroxysmal attacks of ataxia, vertigo, and nausea that usually last hours to days. It is …