Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

High levels of lactate are positively associated with the prognosis and mortality in patients
with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs)
and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent …

Since the crucial role of the microenvironment has been highlighted, many studies have
been focused on the role of biomechanics in cancer cell growth and the invasion of the …

Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell
therapy, however, their treatment efficacy is not satisfactory. Vδ2 T cells are unique to …

Cancer cells program fibroblasts into cancer associated fibroblasts (CAFs) in a two-step
manner. First, cancer cells secrete exosomes to program quiescent fibroblasts into activated …

Oncogene-induced senescence (OIS) is an important process that suppresses tumor
development, but the molecular mechanisms of OIS are still under investigation. It is known …