Is early-onset cancer an emerging global epidemic? Current evidence and future implications

T Ugai, N Sasamoto, HY Lee, M Ando… - Nature Reviews …, 2022 - nature.com
Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Rising incidence of early-onset colorectal cancer—A call to action

N Akimoto, T Ugai, R Zhong, T Hamada… - Nature reviews Clinical …, 2021 - nature.com
The incidence of early-onset colorectal cancer (CRC), which occurs in individuals< 50 years
of age, has been increasing worldwide and particularly in high-income countries. The …

Early‐onset colorectal cancer in young individuals

G Mauri, A Sartore‐Bianchi, AG Russo… - Molecular …, 2019 - Wiley Online Library
Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need,
especially as diagnosis in this population might lead to the greatest loss of years of life …

Emerging trends in colorectal cancer: Dysregulated signaling pathways

R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

The rising incidence of younger patients with colorectal cancer: questions about screening, biology, and treatment

LC Connell, JM Mota, MI Braghiroli, PM Hoff - Current treatment options in …, 2017 - Springer
Opinion statement Colorectal cancer (CRC) is the third leading cancer diagnosed globally
and an important cause of cancer-related mortality. Of interest, while we have witnessed a …

Early-onset colorectal adenocarcinoma in the IDEA database: treatment adherence, toxicities, and outcomes with 3 and 6 months of adjuvant fluoropyrimidine and …

E Fontana, J Meyers, A Sobrero, T Iveson… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Early-onset (EO) colorectal cancer (CRC, age< 50 years) incidence is
increasing. Decisions on optimal adjuvant therapy should consider treatment adherence …

Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold

X Zhu, C Bührer, S Wellmann - Cellular and molecular life sciences, 2016 - Springer
Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are
two evolutionarily conserved RNA-binding proteins that are transcriptionally upregulated in …

Association between younger age and targetable genomic alterations and prognosis in non–small-cell lung cancer

AG Sacher, SE Dahlberg, J Heng, S Mach… - JAMA …, 2016 - jamanetwork.com
Importance Non–small-cell lung cancer (NSCLC) diagnosed in young patients is rare, and
the genomics and clinical characteristics of this disease are poorly understood. In contrast …

[HTML][HTML] Rising proportion of young individuals with rectal and colon cancer

PM Kasi, F Shahjehan, JJ Cochuyt, Z Li… - Clinical colorectal …, 2019 - Elsevier
Background Recent trends have identified increasing number of young individuals with
rectal and colon cancers. These individuals, who are younger than 50 years old, in most …

Chemotherapy use and survival among young and middle-aged patients with colon cancer

J Manjelievskaia, D Brown, KA McGlynn… - JAMA …, 2017 - jamanetwork.com
Importance Treatment options for patients with young-onset colon cancer remain to be
defined and their effects on prognosis are unclear. Objective To investigate receipt of …