Abstract Molecular Lego: Polyketides represent a highly diverse group of natural products
with structurally intriguing carbon skeletons (see picture) which are assembled from simple …

Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …

Polyketide natural products constitute a broad class of compounds with diverse structural
features and biological activities. Their biosynthetic machinery, represented by type I …

In many macroorganisms, the ultimate source of potent biologically active natural products
has remained elusive due to an inability to identify and culture the producing symbiotic …

Abstract Molekulares Lego: Polyketide bilden eine äußerst vielfältige Gruppe von
Naturstoffen mit faszinierenden Kohlenstoffgerüsten (siehe Beispiele), die aus einfachen …

Modular type I polyketide synthases (PKSs) are versatile biosynthetic systems that initiate,
successively elongate, and modify acyl chains. Intermediate transfer between modules is …

Bacterial type I polyketide synthases (PKSs) assemble structurally diverse natural products
of significant clinical value from simple metabolic building blocks. The synthesis of these …

The modular organization of the type I polyketide synthases (PKSs) would seem propitious
for rational engineering of desirable analogous. However, despite decades of efforts, such …

The tubulysins are a family of complex peptides with promising cytotoxic activity against
multi-drug-resistant tumors. To date, ten tubulysins have been described from the …

We report the synthesis and biological activity of a library of aminoalcohol-derived
macrocycles from which robotnikinin (17), a binder to and inhibitor of Sonic Hedgehog, was …