Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor
microenvironment (TME), where it can promote tumor progression or tumor suppression …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic
signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors …

Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

New Findings• What is the topic of this review? This is a personal historical review about the
discovery and the main conceptual advances leading to our current understanding of …

Background: Recent evidence suggests that bone-related parameters are the main
prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated …

Abstract Adenosine 5′‐triphosphate (ATP) was identified in 1970 as the transmitter
responsible for non‐adrenergic, non‐cholinergic neurotransmission in the gut and bladder …

Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …