Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance

BK Rajak, P Rani, P Mandal, RS Chhokar… - Frontiers in …, 2023 - frontiersin.org
Acetyl-CoA carboxylase (ACCase: EC 6.4. 1.2) is one of the essential biotins containing
enzymes required by plants for fatty acid synthesis and elongation. The unique enzyme is …

Strategic lead compound design and development utilizing computer‐aided drug discovery (CADD) to address herbicide‐resistant Phalaris minor in wheat fields

P Rani, BK Rajak, GK Mahato… - Pest Management …, 2024 - Wiley Online Library
Wheat (Triticum aestivum) is a vital cereal crop and a staple food source worldwide.
However, wheat grain productivity has significantly declined as a consequence of …

Sequence and structural similarities of ACCase protein of Phalaris minor and wheat: An insight to explain herbicide selectivity

BK Rajak, P Rani, N Singh, DV Singh - Frontiers in Plant Science, 2023 - frontiersin.org
Uncontrolled growth of Phalaris minor in the wheat (Triticum aestivum) crop has remained a
problem, leading to a massive reduction in wheat grain production. Herbicides have been …

Physicochemical parameters for design and development of lead herbicide molecules: Is 'Lipinski's rule of 5′ appropriate for herbicide discovery?

P Rani, BK Rajak, DV Singh - Pest Management Science, 2023 - Wiley Online Library
BACKGROUND Herbicide use has been a great add‐on in agriculture, aiding weed
management in crop fields, thereby escalating crop production. However, the development …

Target‐site mutations Ile1781Leu and Ile2041Asn in the ACCase2 gene confer resistance to fluazifop‐p‐butyl and pinoxaden herbicides in a johnsongrass accession …

F González‐Torralva, JK Norsworthy - Plant Direct, 2024 - Wiley Online Library
Abstract Johnsongrass [Sorghum halepense (L.) Pers.] is a troublesome weed species in
different agricultural and non‐agricultural areas. Because of its biology, reproductive system …

6-Ethoxy-4-N-(2-morpholin-4-ylethyl)-2-N-propan-2-yl-1, 3, 5-triazine-2, 4-diamine endows herbicidal activity against Phalaris minor a weed of wheat crop field: an in …

N Kumar, P Rani, S Agarwal, DV Singh - Journal of Molecular Modeling, 2022 - Springer
Phalaris minor is a major weed of wheat crop which has evolved resistance against
herbicides. Isoproturon is the most accepted herbicide developed resistance in 1992. Later …