The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Cell polarity, which consists of the morphological, structural, and functional organization of
cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal …

The cell microenvironment choreographs the behaviors of cells through multiple well-
controlled signals. For basic biological study and cell-based therapies, it is essential to …

Inflammation is implicated in cancer genesis and invasiveness and is frequently associated
with a poor prognosis in cancer patients; thus, it becomes a focus of oncology research on …

The war against cancer traces back to the signature event half-a-century ago when the US
National Cancer Act was signed into law. The cancer crusade costs trillions with …

Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic
and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor …

With the growing number of novel therapeutic approaches for liver diseases, significant
research efforts have been devoted to the development of liquid biopsy tools for precision …