Onchocerciasis-associated epilepsy: an update and future perspectives

A Hadermann, LJ Amaral, G Van Cutsem… - Trends in …, 2023 - cell.com
Onchocerciasis-associated epilepsy (OAE) is an important neglected public health problem
in areas with high ongoing onchocerciasis transmission. The risk that children in such areas …

Onchocerca volvulus and epilepsy: A comprehensive review using the Bradford Hill criteria for causation

R Colebunders, AK Njamnshi, S Menon… - PLoS neglected …, 2021 - journals.plos.org
Background The possibility that onchocerciasis may cause epilepsy has been suggested for
a long time, but thus far, an etiological link has not been universally accepted. The objective …

Effect of onchocerciasis elimination measures on the incidence of epilepsy in Maridi, South Sudan: a 3-year longitudinal, prospective, population-based study

SR Jada, LJ Amaral, T Lakwo, JY Carter… - The Lancet Global …, 2023 - thelancet.com
Background High onchocerciasis transmission predisposes endemic communities to a high
epilepsy burden. The 4· 4% epilepsy prevalence documented in 2018 in Maridi, South …

Impact of a bi-annual community-directed treatment with ivermectin programme on the incidence of epilepsy in an onchocerciasis-endemic area of Mahenge …

D Bhwana, LJ Amaral, A Mhina… - PLoS neglected …, 2023 - journals.plos.org
Background Community-directed treatment with ivermectin (CDTi) is used to eliminate
onchocerciasis. However, despite 25 years of annual CDTi in Mahenge, Tanzania, the …

[HTML][HTML] Case definitions for onchocerciasis-associated epilepsy and nodding syndrome: A focused review

G Van Cutsem, JNS Fodjo, MCJ Dekker… - … : European Journal of …, 2023 - Elsevier
Onchocerciasis-associated epilepsy (OAE) is an important but neglected public health
problem in onchocerciasis-endemic areas with insufficient or inadequate onchocerciasis …

A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current …

P Jittamala, W Monteiro, MR Smit… - PLoS neglected …, 2021 - journals.plos.org
Background Oral ivermectin is a safe broad spectrum anthelminthic used for treating several
neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children …

The onchocerciasis hypothesis of nodding syndrome

R Colebunders, A Hadermann… - PLoS neglected tropical …, 2023 - journals.plos.org
Nodding syndrome (NS) is a phenotypic presentation of onchocerciasis-associated epilepsy
(OAE). OAE is an important public health problem in areas with high ongoing Onchocerca …

[HTML][HTML] Mapping, associated factors, and pathophysiology of nodding syndrome in Africa: A systematic review

S Metanmo, D Dossa, DN Ahmat, AS Winkler… - …, 2024 - karger.com
Introduction: Nodding syndrome (NS) remains a poorly understood disorder. For a long time,
it has been thought to be restricted to East Africa; however, cases in Central Africa have …

The role of the Maridi Dam in causing an onchocerciasis-associated epilepsy epidemic in Maridi, South Sudan: an epidemiological, sociological, and entomological …

TL Lakwo, S Raimon, M Tionga, JN Siewe Fodjo… - Pathogens, 2020 - mdpi.com
Background: An epilepsy prevalence of 4.4% was documented in onchocerciasis-endemic
villages close to the Maridi River in South Sudan. We investigated the role of the Maridi dam …

The prevalence of onchocerciasis-associated epilepsy in Mundri West and East Counties, South Sudan: A door-to-door survey

SR Jada, A Dusabimana, G Abd-Elfarag, S Okaro… - Pathogens, 2022 - mdpi.com
A two-phase survey of epilepsy was conducted in selected villages in Mundri West and East
Counties (26 June–8 July, 2021), an onchocerciasis-endemic area in Western Equatoria …